Immune Recognition of Candida albicans -glucan by Dectin-1
نویسندگان
چکیده
Neil A. R. Gow,1,a Mihai G. Netea,2,a Carol A. Munro,1 Gerben Ferwerda,2,3 Steven Bates,1 Héctor M. Mora-Montes,1 Louise Walker,1 Trees Jansen,2,3 Liesbeth Jacobs,2,3 Vicky Tsoni,4 Gordon D. Brown,4 Frank C. Odds,1 Jos W. M. Van der Meer,2,3 Alistair J. P. Brown,1 and Bart Jan Kullberg2,3 1School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom; 2Department of Medicine, Radboud University Nijmegen Medical Center, and 3Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands; 4Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Groote Schuur Campus, Cape Town, South Africa
منابع مشابه
Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.
The ability of Candida albicans to rapidly and reversibly switch between yeast and filamentous morphologies is crucial to pathogenicity, and it is thought that the filamentous morphology provides some advantage during interaction with the mammalian immune system. Dectin-1 is a receptor that binds beta-glucans and is important for macrophage phagocytosis of fungi. The receptor also collaborates ...
متن کاملCandida albicans beta-glucan exposure is controlled by the fungal CEK1-mediated mitogen-activated protein kinase pathway that modulates immune responses triggered through dectin-1.
Innate immunity to Candida albicans depends upon the recognition of molecular patterns on the fungal cell wall. However, the masking of major components such as beta-glucan seems to be a mechanism that fungi have evolved to avoid immune cell recognition through the dectin-1 receptor. Although the role of C. albicans mitogen-activated protein kinase (MAPK) pathways as virulence determinants has ...
متن کاملDifferential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching.
Glucans are structurally diverse fungal biopolymers that stimulate innate immunity and are fungal pathogen-associated molecular patterns. Dectin-1 is a C-type lectin-like pattern recognition receptor that binds glucans and induces innate immune responses to fungal pathogens. We examined the effect of glucan structure on recognition and binding by murine recombinant Dectin-1 with a library of na...
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The β-glucan receptor Dectin-1 is a member of the C-type lectin family and functions as an innate pattern recognition receptor in antifungal immunity. In both mouse and man, Dectin-1 has been found to play an essential role in controlling infections with Candida albicans, a normally commensal fungus in man which can cause superficial mucocutaneous infections as well as life-threatening invasive...
متن کاملA computational model for regulation of nanoscale glucan exposure in Candida albicans
Candida albicans is a virulent human opportunistic pathogen. It evades innate immune surveillance by masking an immunogenic cell wall polysaccharide, β-glucan, from recognition by the immunoreceptor Dectin-1. Glucan unmasking by the antifungal drug caspofungin leads to changes in the nanostructure of glucan exposure accessible to Dectin-1. The physical mechanism that regulates glucan exposure i...
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Dectin-1, which specifically recognizes β-glucan of fungal cell walls, is a non-Toll-like receptor (TLR) pattern recognition receptor and a representative of C-type lectin receptors (CLRs). The importance of Dectin-1 in innate immune cells, such as dendritic cells and macrophages, has previously been well studied. However, the function of Dectin-1 in B cells is very poorly understood. To determ...
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